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KMID : 0043319970200010080
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Archives of Pharmacal Research
1997 Volume.20 No. 1 p.80 ~ p.84
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Synthesis of Substituted Cinnamoyl-tyramine Derivatives and their platelet Anti-aggregatory Activities
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Woo Nam-Tae
Jin Sung-Yong
Cho Dae-Jin
Kim Nam-Sun
Bae Eun-Hyung
Han Ducky
Han Byung-Hoon
Kang Young-Hwa
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Abstract
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Substituted cinnamoyl-tyramine derivatives were synthesized by DCC-coupling of substituted cinnamic acid with tyramine or tyramine methyl-1-ether to evaluate PAF-receptor binding antagonistic activities and inhibitory activities on PAF-induced platelet aggregation with interest on structure-activity relations. The results show that 3,4-dimethoxy-cinnamoyl tyramine-amide or its methyl ether have significant PAF-receptor binding antagonistic activity and platelet anti-aggregatory activities.
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KEYWORD
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Platelet anti-aggregatory activities, PAF-receptor binding antagonistic activity, Sub-stituted cinnamoyl tyramine amide
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